Friday, May 29, 2015

Biophotonics Faculty Candidate Seminar: "Analysis of Protein Fibers Using Nonlinear Optical Microscopy and Spectroscopy" by Dr. Patrick Koelsch 6.5.15/11:00am-12:00pm/ CREOL RM 102

Seminar: "Analysis of Protein Fibers Using Nonlinear Optical Microscopy and Spectroscopy" by Dr. Patrick Koelsch
Friday, June 5, 2015 11:00 AM to 12:00 PM
CREOL Room 102

Celebrating the International Year of Light 2015

Patrick Koelsch
Department of Bioengineering, University of Washington, Seattle.

Protein fibers are a common motif in nature, often essential for the structural integrity of living entities. From a biomedical standpoint, protein fibers occur in the context of many disease related phenomena such as Alzheimer’s and Parkinson’s disease, diabetes mellitus, cancer, or muscular dystrophy - to name a few. This lecture will describe the application of nonlinear optical microscopy and spectroscopy to study the structure of protein fibers, dynamics at early stages of fibril formation, and interaction of protein fibers with other molecules. Examples will include second-harmonic generation (SHG) and sum-frequency generation (SFG) probing schemes that we designed, developed and applied to analyze bone structure, muscle fibers, amyloid fibers in bacterial biofilms, and amyloid structures that occur in Alzheimer’s disease.

Professor Koelsch is a faculty member in the Bioengineering Department at the University of Washington. He received his doctoral degree in 2005 while working with Professor Helmuth Mohwald at the Max-Planck-Institute of Colloid and Interface Science. His doctoral research focused on ion specific effects and static and dynamic properties of soluble surfactants at the air/water interface. After a short postdoctoral phase at the University of Leipzig, Professor Koelsch joined the faculty in the Department of Chemistry at the University of Heidelberg where he became an Associate Professor in 2010 (“Privatdozent”). In 2008, Dr. Koelsch was additionally appointed as a research group leader at the Karlsruhe Institute of Technology before moving to Seattle in 2011. His laboratory is broadly interested in the behavior of molecules at interfaces with a focus on developing and applying nonlinear optical spectroscopy and imaging techniques.

For additional information:
Dr. Aristide Dogariu


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