Seminar: "Label-free cellular imaging and tissue
turbidity suppression" by Dr. Zahid Yaqoob
Monday, February 24, 2014 11:00 AM to 12:00 PM
CREOL Room 102
CREOL Room 102
Dr. Zahid Yaqoob
Laser Biomedical Research Center
Massachusetts Institute of Technology
Abstract:
Optical imaging and spectroscopy of biological cells and
tissue can provide tremendous information that may be utilized for both
diagnostic and therapeutic applications. A major challenge in optical imaging,
however, is to elicit relevant information in a label-free fashion. While cells
are generally transparent that leads to diminished image contrast, biological
tissue is highly scattering that limits the working depth range of current
optical imaging and spectroscopy modalities. Remarkably, quantitative analysis
of amplitude and phase characteristics of the transmitted or backscattered
light can lead to label-free structural and functional imaging in live cells. I
will discuss the development of two- and three-dimensional quantitative phase
microscopy and its applications including dry mass (non-aqueous content)
measurements to study cell growth and division. Accurate optical field-based
measurements can also be utilized to quantify and control multiple light
scattering in turbid media. This topic has attracted significant interest in
recent years, leading to different approaches for overcoming tissue turbidity.
I will present active wavefront control via optical phase conjugation and
demonstrate its efficacy in permitting high-fidelity wide-field imaging through
turbid media.
Biography:
Dr. Yaqoob obtained his MS and PhD in Optics from The
College of Optics and Photonics/CREOL, University of Central Florida. He
received his postdoctoral training in biomedical optics at CalTech and MIT. He
is currently a Research Scientist at the MIT Laser Biomedical Research Center,
where his research is focused on developing innovative photonic solutions for
complex problems in biological research and medical diagnosis. He is
particularly interested in applying these tools to understand highly regulated
physiological and pathological processes at single cell level. His research
also focuses on developing strategies to harness multiple light scattering in
biological tissue with the aim to improve the working depth range of current
optical imaging and spectroscopy tools. He has published in more than 85
peer-reviewed journals and conference proceedings.
For additional information:
Dr. M. G. "Jim"
Moharam
Professor of Optics
407-823-6833
moharam AT creol . ucf . edu
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