CREOL Room 102
Tuesday, February 18, 2014
Seminar: "Developing photoacoustic imaging technologies and optical coherence tomography for clinical applications and the “BRAIN” initiative" by Bin Rao 2.28.14/10:30am-11:30am/CREOL 102
Seminar: "Developing photoacoustic imaging technologies and optical coherence tomography for clinical applications and the “BRAIN” initiative" by Bin Rao
Friday, February 28, 2014 10:30 AM to 11:30 AM
CREOL Room 102
CREOL Room 102
Photoacoustic imaging (PAI) technologies are hybrid optical imaging technologies that acoustically detect optical absorption contrasts via the photoacoustic effect. Major PAI technologies include photoacoustic computed tomography (PACT), acoustic-resolution photoacoustic microscopy (AR-PAM) and optical-resolution photoacoustic microscopy (OR-PAM). The major strengths of PAI are the deep imaging capability of PACT and AR-PAM, and the functional, high resolution, optical absorption contrast images of reflection mode OR-PAM. Optical coherence tomography (OCT) forms three-dimensional tissue structure images by probing weak back-scattered photons with coherent gating and coherent amplification. OCT offers high sensitivity, and provides functional, high resolution optical scattering contrast images. Major PAI and OCT imaging systems and applications that I developed at the Beckman Laser Institute & Medical Clinic of University of California, Irvine (BLIMC-UCI), and at Washington University in St. Louis are reviewed. Highlights are the spectral Doppler imaging and quantification of pulsatile retinal blood flow of human patients at BLIMC-UCI, in vivo recording of epilepsy seizure in a small animal model by a dual-modality PAM and OCT imaging system, and the development of miniature OR-PAM imaging probes for imaging port-wine stain (PWS) in children. Finally, I will discuss developing PAI and OCT for both clinical applications and the “BRAIN” initiative(a bold new research effort to revolutionize our understanding of the human mind and uncover new ways to treat, prevent, and cure brain disorders like Alzheimer’s, schizophrenia, autism, epilepsy, and traumatic brain injury).
Bin Rao received his Ph.D. on biomedical optics from Beckman Laser Institute & Medical clinic, University of California, Irvine (BLIMC-UCI) in 2008. His post-doctor trainings at Washington University in Saint Louis include photoacoustic microscopy, confocal, and two-photon microscopy. He has built two clinical imaging systems, including the spectral Doppler optical coherence tomography instrument for quantifying pulsatile retinal blood flow, and the photoacoustic microscopy system for imaging port-wine stain in children. Both clinical imaging systems are being used by clinicians in clinical studies at BLIMC-UCI. He was awarded the NIH Pathway to Independence Award in 2012.
For additional information:
Dr. Bahaa E. A. Saleh
Dean & Director, Professor of Optics
besaleh AT creol . ucf . edu