Seminar: "Developing photoacoustic imaging
technologies and optical coherence tomography for clinical applications and the
“BRAIN” initiative" by Bin Rao
Friday, February 28, 2014 10:30 AM to 11:30 AM
CREOL Room 102
CREOL Room 102
Abstract:
Photoacoustic imaging (PAI) technologies are hybrid optical
imaging technologies that acoustically detect optical absorption contrasts via
the photoacoustic effect. Major PAI technologies include photoacoustic computed
tomography (PACT), acoustic-resolution photoacoustic microscopy (AR-PAM) and
optical-resolution photoacoustic microscopy (OR-PAM). The major strengths of
PAI are the deep imaging capability of PACT and AR-PAM, and the functional,
high resolution, optical absorption contrast images of reflection mode OR-PAM.
Optical coherence tomography (OCT) forms three-dimensional tissue structure
images by probing weak back-scattered photons with coherent gating and coherent
amplification. OCT offers high sensitivity, and provides functional, high
resolution optical scattering contrast images. Major PAI and OCT imaging
systems and applications that I developed at the Beckman Laser Institute &
Medical Clinic of University of California, Irvine (BLIMC-UCI), and at
Washington University in St. Louis are reviewed. Highlights are the spectral
Doppler imaging and quantification of pulsatile retinal blood flow of human
patients at BLIMC-UCI, in vivo recording of epilepsy seizure in a small
animal model by a dual-modality PAM and OCT imaging system, and the development
of miniature OR-PAM imaging probes for imaging port-wine stain (PWS) in
children. Finally, I will discuss developing PAI and OCT for both clinical
applications and the “BRAIN” initiative(a bold new research effort to
revolutionize our understanding of the human mind and uncover new ways to
treat, prevent, and cure brain disorders like Alzheimer’s, schizophrenia,
autism, epilepsy, and traumatic brain injury).
Biography:
Bin Rao received his Ph.D. on biomedical optics from Beckman
Laser Institute & Medical clinic, University of California, Irvine
(BLIMC-UCI) in 2008. His post-doctor trainings at Washington University in
Saint Louis include photoacoustic microscopy, confocal, and two-photon
microscopy. He has built two clinical imaging systems, including the spectral
Doppler optical coherence tomography instrument for quantifying pulsatile
retinal blood flow, and the photoacoustic microscopy system for imaging
port-wine stain in children. Both clinical imaging systems are being used by
clinicians in clinical studies at BLIMC-UCI. He was awarded the NIH Pathway to
Independence Award in 2012.
For additional information:
Dr. Bahaa E. A. Saleh
Dean & Director, Professor of Optics
407-882-3326
besaleh AT creol . ucf . edu
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