"Cells as Bits: Biomedical Diagnostics Inspired
by Wideband Data Multiplexing Techniques" by Bahram Jalali
Tuesday, October 08, 2013 11:00 AM to 12:00 PM
CREOL Room 102
Bahram Jalali, UCLA
Abstract:
Telecommunication systems routinely generate, capture and
analyze data at rates exceeding billions of bits per second. Interestingly, the
scale of the problem is similar to that of blood analysis. With approximately 1
billion cells per milliliter of blood, detection of a few abnormal cells in a
blood sample translates into a “cell error rate” of 10-12, a value strangely
similar to the bit error rate in telecommunication systems.
Motivated by WDM and time-stretch dispersive Fourier
transform technologies, a new type of bright-field imaging known as STEAM has
demonstrated imaging of cells with record shutter speed and throughput leading
to detection of rare breast cancer cells in blood with one-in-a-million
sensitivity. A second technique called FIRE is a new approach to fluorescent
imaging that is based on wireless communication techniques. FIRE has achieved
real-time pixel readout rates one order of magnitude faster than the current
gold standard in high-speed fluorescence imaging.
Finally, a new physics-based signal transformation will be
introduced and demonstrated. It enables a digitizer to capture signals that
would otherwise be beyond its bandwidth and at the same time, it compresses the
digital data volume. This method is inspired by operation of Fovea centralis in
the human eye and by anamorphic transformation in visual arts. The so-called
Anamorphic Spectrum Transformation makes it possible to (i) capture
high-throughput random signals in real-time and (ii) to alleviate the storage
and transmission bottlenecks associated with the resulting “big data”.
Biography:
Prof. Jalali is the Northrop-Grumman Endowed Chair in
Optoelectronics and Professor of Electrical Engineering at UCLA, the Director
of Department’s Physical and Wave Electronics, with joint appointments in
Biomedical Engineering, California NanoSystems Institute (CNSI) and Department
of Surgery at the UCLA School of Medicine. He received his Ph.D. in Applied
Physics from Columbia University in 1989 and was with Bell Laboratories in
Murray Hill, New Jersey until 2002 before joining UCLA. He is a Fellow of IEEE,
the Optical Society of America (OSA), and the American Physical Society (APS).
He is the recipient of the R.W. Wood Prize from Optical Society of America for
the invention and demonstration of the first Silicon Laser, and the Aron
Kressel Award of the IEEE Photonics Society, and the Distinguished Engineering
Achievement Award from the Engineers Council. In 2005 he was elected into the
Scientific American Top 50, and received the BrideGate 20 Award in 2001 for his
entrepreneurial accomplishments. He has published over 300 journal and
conference papers, and holds 11 patents. During 2001-2004, he was a consultant
at Intel Corporation’s optical and wireless communication divisions.
For more information:
Dr. Sasan Fathpour
Assistant Professor of Optics
407-823-6961
No comments:
Post a Comment