Seminar: "Analysis of Protein Fibers Using Nonlinear
Optical Microscopy and Spectroscopy" by Dr. Patrick Koelsch
Friday, June 5, 2015 11:00 AM to 12:00 PM
CREOL Room 102
CREOL Room 102
Celebrating the International Year of Light 2015
Patrick Koelsch
Department of Bioengineering, University of Washington,
Seattle.
Abstract:
Protein fibers are a common motif in nature, often essential
for the structural integrity of living entities. From a biomedical standpoint,
protein fibers occur in the context of many disease related phenomena such as
Alzheimer’s and Parkinson’s disease, diabetes mellitus, cancer, or muscular
dystrophy - to name a few. This lecture will describe the application of
nonlinear optical microscopy and spectroscopy to study the structure of protein
fibers, dynamics at early stages of fibril formation, and interaction of
protein fibers with other molecules. Examples will include second-harmonic
generation (SHG) and sum-frequency generation (SFG) probing schemes that we
designed, developed and applied to analyze bone structure, muscle fibers,
amyloid fibers in bacterial biofilms, and amyloid structures that occur in
Alzheimer’s disease.
Biography:
Professor Koelsch is a faculty member in the Bioengineering
Department at the University of Washington. He received his doctoral degree in
2005 while working with Professor Helmuth Mohwald at the Max-Planck-Institute
of Colloid and Interface Science. His doctoral research focused on ion specific
effects and static and dynamic properties of soluble surfactants at the
air/water interface. After a short postdoctoral phase at the University of
Leipzig, Professor Koelsch joined the faculty in the Department of Chemistry at
the University of Heidelberg where he became an Associate Professor in 2010
(“Privatdozent”). In 2008, Dr. Koelsch was additionally appointed as a research
group leader at the Karlsruhe Institute of Technology before moving to Seattle
in 2011. His laboratory is broadly interested in the behavior of molecules at
interfaces with a focus on developing and applying nonlinear optical
spectroscopy and imaging techniques.
For additional information:
Dr. Aristide Dogariu
407-823-6839
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