Wednesday, September 3, 2014

Seminar: "Recent advances in LIBS instrumentation: Application in quantification and elemental imaging" by Vincent Motto-Ros 9.26.14/ 11:00am-12:00pm/ CREOL Room 103

Seminar: "Recent advances in LIBS instrumentation: Application in quantification and elemental imaging" by Vincent Motto-Ros
Friday, September 26, 2014 11:00 AM to 12:00 PM
CREOL Room 103

Laser-Induced Breakdown Spectroscopy (LIBS) is recognized as a promising technique which enables elemental analysis of any type of material. It is extremely versatile with high potential in term of applications, offering standoff analysis capability, requiring only simple sample preparation, and providing fast and real-time analysis. However, improving the repeatability and the reproducibility of LIBS measurements is still the challenging issue faced by the technique to fit the requirements of precise and accurate quantitative analysis.
In the first part of this presentation, I will describe a new generation of LIBS instrument developed in our institute. The basic instrumental concept is to assist, either manually or automatically, the optical detection fiber by a real-time imaging of the plasma. This tends to improve greatly the stability of LIBS measurement in short as well in long terms [1], allowing unprecedented level of performances in elemental quantification (c.f. fig. 1a.). In the second part, some of our recent results will be presented in the frame of elemental imaging of biological tissue. We will show different examples of elemental images, sections of tumors and murine kidneys, with an investigation focused on the renal clearance of theranostic gadolinium-based nanoparticles (Fig. 1b.). The efficiency of LIBS imaging allows elements being mapped and quantified in tissues without any labeling and with an instrumentation fully compatible with standard optical microscope systems, offering a valuable tools in the fields of nanotechnology, biology, as well as medicine. [2].

Fig. 1. a) Example of calibration curve typically obtained with our LIBS setup. b) Elemental imaging principle and example of images obtained for a section of murine kidneys with 20 µm space resolution.

[1]   Motto-Ros, V et al. Precise alignment of the collection fiber assisted by real-time plasma imaging in laser-induced breakdown spectroscopy. Spectrochim. Acta B 92, 60-69 (2014).
[2]   Sancey, L. et al. Laser spectrometry for multi-elemental imaging of biological tissues, Sc. Rep. 4, 6065 (2014).

Associated Professor, Institut Lumière Matière, Université Claude Bernard Lyon 1, Domaine Scientifique de La Doua, Bâtiment Kastler, 69622 Villeurbanne, France
Vincent Motto-Ros graduated with a M.S. in "Laser and Spectroscopy" in the University of Lyon (France) in 2002 and continued to complete his Ph.D. in the 'Laboratoire de Spectrométrie Ionique et Moléculaire' (Lasim, Lyon) working on "high-precision and high-sensitive spectroscopy of gaseous molecular species (O2, H2O, NO2) using high finesse cavities pumped by CW laser diode" under the direction of Pr. Patrick Rairoux. He starts his research on LIBS in 2007 with a post-Doc position in the Canadian Space Agency for which he demonstrated the potential of artificial neural network (ANN) in LIBS data processing for material identification and quantitative measurements of elements of planetological interest. He was recruited in 2008 by the Lyon 1 University as Associated Professor in the Jin Yu’s team (LASIM, called now Light and Matter Institute). He developed advanced experimental setups for fundamental research as well as applications related to laser-induced plasma. His panel covers the fundamentals of laser-induced plasmas, the application of laser spectroscopies such as LIBS, Fluorescence and Raman, as fundamental diagnostics as well as sensing techniques for industrial, environmental, geological and biomedical applications.

For additional information:  
Dr. Matthieu Baudelet

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